Experimenrtal cholestasis is associated with increased IL-17 and IFN-? expression

Liver fibrogenesis due to cholestasis is associated with increased Smad7 expression and Smad3 signaling

BACKGROUND/AIMS Profibrogenic TGF-beta signaling in hepatic stellate cells is modulated during transdifferentiation. Strategies to abrogate TGF-beta effects provide promising antifibrotic results, however, in vivo data regarding Smad activation during fibrogenesis are scarce. METHODS Here, liver fibrosis was assessed subsequent to bile duct ligation by determining liver enzymes in serum and c...

Effects of 1,25-dihydroxyvitamin D3 on IL-17/IL-23 axis, IFN-γ and IL-4 expression in systemic lupus erythematosus induced mice model

Objective(s): Systemic lupus erythematosus (SLE) is a multi-factorial autoimmune disease which may be characterized by T lymphocytes dysfunctions. Th17 cells have been identified as new effector cells, which play an important role in the pathogenesis. In recent years, immunomodulatory effect of vitamin D3 has been noticed. In the present experiment, the effect of vitamin D3 on the expression of...

Dendritic Cells Amplifies IL-17 Production Increased Osteopontin Expression in

Vitamin D deficiency is associated with increased IL-17 and TNFα levels in patients with chronic heart failure.

BACKGROUND Recent studies revealed a strong association between vitamin D (VD) status and chronic heart failure (CHF). It is now commonly considered that proinflammatory immune response underlies CHF development. OBJECTIVE Since VD expresses anti-inflammatory properties, we investigated its impact on cytokines implicated in CHF, such as TNFα and IL-17, in patients suffering from CHF. METHOD...

plasma levels of ifn-γ, il-4, il-6 and il-17 in hiv-positive patients with oral candidiasis

patients and methods in total, 98 samples in four groups (hiv-positive and hiv-negative persons with and without oc) were obtained from the oral cavities and cultured on sabouraud’s dextrose agar and chromagar. also blood samples were obtained to assess plasma level of ifn-γ, il-4, il-6 and il-17 using elisa technique. background cell-mediated immunity (cmi) by cd4 + th (t helper)-type cells is...